Overview of Teratology

Carole A. Kimmel1

1 U.S. Environmental Protection Agency, Washington, D.C
Publication Name:  Current Protocols in Toxicology
Unit Number:  Unit 13.1
DOI:  10.1002/0471140856.tx1301s06
Online Posting Date:  May, 2001
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Abstract

Teratology is the study of developmental processes to understand the causes and mechanisms of abnormal developmental outcomes. This unit provides an explanation of the basic principles of the field as a context for the more specialized protocol units to follow in the chapter.

     
 
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Table of Contents

  • Historical Perspective
  • Principles of Teratology and Abnormal Development
  • Extrapolation of Animal Findings to Humans
  • Use of In Vitro Systems in Teratology
  • Literature Cited
  • Tables
     
 
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Materials

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Figures

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Literature Cited

Literature Cited
   Brent, R.L. 1977. Radiations and other physical agents. In Handbook of Teratology, Vol. 1 (J.G. Wilson and F.C. Fraser, eds.) pp. 153‐223. Plenum Press, New York.
   Brown, N.A. 1994. Mechanisms of early embryogenesis. In Developmental Toxicology (C.A. Kimmel and J. Buelke‐Sam, eds.) pp. 15‐49. Raven Press, New York.
   Catalano, P.J., Scharfstein, D.O., Ryan, L.M., Kimmel, C.A., and Kimmel, G.L. 1993. A statistical model for fetal death, fetal weight, and malformation in developmental toxicity studies. Teratology 47:281‐290.
   Daston, G.P. 1994. Relationships between maternal and developmental toxicity. In Developmental Toxicology (C.A. Kimmel and J. Buelke‐Sam, eds.) pp. 189‐212. Raven Press, New York.
   Faustman, E.M., Ponce, R.A., Seeley, M.R., and Whittaker, S.G. 1997. Experimental approaches to evaluate mechanisms of developmental toxicity. In Handbook of Developmental Toxicology (R.D. Hood, ed.) pp. 13‐41. CRC Press, Boca Raton, Fla.
   Gerhart, J. 1998. Warkany Lecture: Signalling pathways in development. Teratology 60:226‐239.
   Hales, B.F. and Robaire, B. 1997. Paternally mediated effects on development. In Handbook of Developmental Toxicology (R.D. Hood, ed.) pp. 91‐107. CRC Press, Boca Raton, Fla.
   Harris, C. 1997. In vitro methods for the study of mechanisms of developmental toxicity. In Handbook of Developmental Toxicology (R.D. Hood, ed.) pp. 465‐509. CRC Press, Boca Raton, Fla.
   Hood, R.D. and Miller, D.B. 1997. Maternally mediated effects on development. In Handbook of Developmental Toxicology (R.D. Hood, ed.) pp. 61‐90. CRC Press, Boca Raton, Fla.
   Hwang, S.J., Beaty, T.H., and Panny, S. et al. 1995. Association study of transforming growth factor alpha (TGF α) Taql polymorphism and oral clefts: Indication of gene‐environment interaction in a population‐based sample of infants with birth defects. Am. J. Epidemiol. 141:629‐636.
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   Sadler, T.W. and Hunter, E.S. 1994. Principles of abnormal development. Past, present and future. In Developmental Toxicology (C.A. Kimmel and J. Buelke‐Sam, eds). pp. 53‐63. Raven Press, New York.
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