Strategies for Bioactive Small Molecule Discovery

Listings: 1-20   21-36
Alphabetical     Date
High‐Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor
Peter K. Foote, David T. Krist, Alexander V. Statsyuk
Published online: September 2017
Overview of Methods and Strategies for Conducting Virtual Small Molecule Screening
Xavier Fradera, Kerim Babaoglu
Published online: September 2017
UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis
David T. Krist, Peter K. Foote, Alexander V. Statsyuk
Published online: March 2017
Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography‐Mass Spectrometry
Christian Jäger, Karsten Hiller, Manuel Buttini
Published online: September 2016
Measurement of Receptor Signaling Bias
Terry Kenakin
Published online: September 2016
Combinatorial Library Screening Coupled to Mass Spectrometry to Identify Valuable Cyclic Peptides
Silvia A. Camperi, Silvana L. Giudicessi, María C. Martínez‐Ceron, Juan M. Gurevich‐Messina, Soledad L. Saavedra, Gerardo Acosta, Osvaldo Cascone, Rosa Erra‐Balsells, Fernando Albericio
Published online: June 2016
Hollow‐Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds
Emily Caton, Elizabeth Nenortas, Rahul P. Bakshi, Theresa A. Shapiro
Published online: March 2016
A Bead‐Based Proximity Assay for BRD4 Ligand Discovery
Justin M. Roberts, James E. Bradner
Published online: December 2015
Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes (hiPSC‐CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways
Liang Guo, Sandy Eldridge, Mike Furniss, Jodie Mussio, Myrtle Davis
Published online: September 2015
Probing Small‐Molecule Microarrays with Tagged Proteins in Cell Lysates
Marius S. Pop, Dina Wassaf, Angela N. Koehler
Published online: December 2014
Evaluation of Compounds in Primary Human Islet Cell Culture
Deepika Walpita, Bridget K. Wagner
Published online: September 2014
Manipulating Natural Product Biosynthetic Pathways via DNA Assembler
Zengyi Shao, Huimin Zhao
Published online: June 2014
Label‐Free Cell‐Based Dynamic Mass Redistribution Assays
Hannah J. Gitschier, Audrey B. Bergeron, David H. Randle
Published online: March 2014
Saturation Transfer Difference NMR for Fragment Screening
Darren W. Begley, Spencer O. Moen, Phillip G. Pierce, Edward R. Zartler
Published online: December 2013
Characterization of Cannabinoid Receptors
Richard F. Cox, Vincent Rash
Published online: December 2013
Multiplexing High‐Content Flow (HCF) and Quantitative High‐Throughput Screening (qHTS) to Identify Compounds Capable of Decreasing Cell Viability, Activating Caspase 3/7, Expressing Annexin V, and Changing Mitochondrial Membrane Integrity
Lesley A. Mathews, Jonathan M. Keller, Crystal McKnight, Sam Michael, Paul Shinn, Dongbo Liu, Louis M. Staudt, Craig J. Thomas, Marc Ferrer
Published online: October 2013
Profiling Native Kinases by Immuno‐Assisted Activity‐Based Profiling
Eric Okerberg, Ann Shih, Heidi Brown, Senait Alemayehu, Arwin Aban, Tyzoon K. Nomanbhoy
Published online: October 2013
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