Safety Pharmacology/Toxicology

Listings: 1-20   21-30
Alphabetical     Date
Minipigs: Applications in Toxicology
Larry D. Brown, Alain Stricker‐Kongrad, Guy F. Bouchard
Published online: May 2013
Assessment of Substance Abuse Liability in Rodents: Self‐Administration, Drug Discrimination, and Locomotor Sensitization
Neil E. Paterson
Published online: September 2012
Assessment of P‐Glycoprotein Substrate and Inhibition Potential of Test Compounds in MDR1‐Transfected MDCK Cells
Kevin C. L. Lam, Ganesh Rajaraman
Published online: September 2012
Assessment of the Time‐Dependent Inhibition (TDI) Potential of Test Compounds with Human Liver Microsomes by IC50 Shift Method Using a Nondilution Approach
Lian de Ron, Ganesh Rajaraman
Published online: September 2012
Whole‐Cell Configuration of the Patch‐Clamp Technique in the hERG Channel Assay to Predict the Ability of a Compound to Prolong QT Interval
Sonia Goineau, Christophe Legrand, Guillaume Froget
Published online: June 2012
Models of Neurological Disease (Substance Abuse): Self‐Administration in Monkeys
Donna M. Platt, Galen Carey, Roger D. Spealman
Published online: March 2012
Overview of Drug Product Development
Padma Narayan
Published online: December 2011
Measurement of Action Potential Generation in Isolated Canine Left Ventricular Midmyocardial Myocytes
Daniel M. Johnson, Leyla Hussein, Roel L.H.M.G. Spätjens, Jean‐Pierre Valentin, Paul G.A. Volders, Najah Abi‐Gerges
Published online: December 2011
The Fentanyl/Etomidate‐Anesthetized Beagle (FEAB) Model in Safety Pharmacology Assessment
Henk J. van der Linde, Bruno Van Deuren, Yves Somers, Ard Teisman, David J. Gallacher
Published online: September 2011
Measuring Receptor Target Coverage: A Radioligand Competition Binding Protocol for Assessing the Association and Dissociation Rates of Unlabeled Compounds
David A. Sykes, Mark R. Dowling, Steven J. Charlton
Published online: September 2010
Measurement of Gastric Acid Secretion in the Anaesthetized Rat
Maristella Adami, Gabriella Coruzzi
Published online: August 2010
Acute Seizure Tests in Epilepsy Research: Electroshock‐ and Chemical‐Induced Convulsions in the Mouse
William J. Giardina, Maciej Gasior
Published online: June 2009
Models of Cardiovascular Disease: Measurement of Arrhythmogenic/Antiarrhythmic Activity in the Guinea Pig
Philippe Guillaume, Daniel Provost, Pierre Lacroix
Published online: March 2009
Models of Cardiovascular Disease: Measurement of Antihypertensive Activity in the Conscious Rat (SHR, DOCA‐Salt, and Goldblatt Hypertension Models)
Philippe Guillaume, Daniel Provost, Pamela Legrand, Michael Godes, Pierre Lacroix
Published online: March 2009
Overview of Pharmacogenetics
David A. Katz
Published online: March 2007
Toxicology Testing in Drug Discovery and Development
Michael A. Dorato, Lorrene A. Buckley
Published online: February 2007
Toxicity Testing in Chemical Safety Evaluation
James S. Bus
Published online: February 2007
An Overview of QT Interval Assessment in Safety Pharmacology
Pierre Lacroix, Sandra Picard
Published online: July 2006
Head‐Out Plethysmography in Safety Pharmacology Assessment
Jonathan P. Renninger
Published online: July 2006
The Action Potential of the Purkinje Fiber: An In Vitro Model for Evaluation of the Proarrhythmic Potential of Cardiac and Noncardiac Drugs
Sandra Picard, Sonia Goineau, Rene Rouet
Published online: July 2006
Listings: 1-20   21-30