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Monitoring Tumor Therapy

Annette O. Nusbaum¹, Scott W. Atlas²

¹New York Presbyterian Hospital, New York, New York
²Stanford University Medical Center, Stanford, California

Publication Name:

Current Protocols in Magnetic Resonance Imaging

Unit Number:

Unit A3.5

DOI:

10.1002/0471142719.mia0305s00

Online Posting Date:

May, 2001

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Abstract

This unit presents the preferred protocol for imaging the brain following the institution of chemotherapy, radiation therapy, or surgery for brain tumors and specific modifications are discussed where necessary. The sequences described in this unit are based on a 1.5 T scanner (Echospeed GE Medical Systems), but can be expected to be equally applicable to other field strengths and scanners from other manufacturers.

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Unit Introduction
Basic Protocol: Follow-Up Post Surgery
Basic Protocol 1: Radiation Necrosis Versus Tumor Recurrence
Commentary
Literature Cited
Tables

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Materials

Basic Protocol: Follow-Up Post Surgery

Materials

Intravenous contrast agent (e.g., Magnevist, Omniscan, Prohance)
Normal saline (0.9% NaCl), sterile

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Literature Cited

Literature Cited
	Atlas, S.W. and Lavi, E. 1996. Intra-axial brain tumors. In Magnetic Resonance Imaging of the Brain and Spine. 2nd Edition (S.W. Atlas, ed.). pp. 315-422. Lippincott-Raven, Philadelphia.
	Grossman, R.I., Hecht-Leavitt, C.M., Evans, S.M., Lenkinski, R.E., Holland, G.A., Van Winkle, T.J., McGrath, J.T., Curran, W.J., Shetty, A., and Joseph, P.M. 1988. Experimental radiation injury: Combined MR imaging and spectroscopy. Radiology. 169:305-309.
	Nelson, S.J., Vigneron, D.B., and Dillon, W.P. 1999. Serial evaluation of patients with brain tumors using volume MRI and 3D 1H MRSI. N.M.R. Biomed. 12:123-138.
	Ricci, P.E., Pitt, A., Keller, P.J., Coons, S.W., and Heiserman, J.E. 2000. Effect of voxel position on single-voxel MR spectroscopy findings. Am. J. Neuroradiol. 21:367-374.
	Shellock, F.G. 1996. Pocket Guide to MR Procedures and Metallic Objects. Lippincott-Raven, Philadelphia.
	Sijens, P.E., van den Bent, M.J., Nowak, P.J., van Dijk, P., and Ouderk, M. 1997. ¹H chemical shift imaging reveals loss of brain tumor choline signal after administration of Gd-contrast. Magn. Reson. Med. 37:222-225.
	Taylor, J.S., Langston, J.W., Reddick, W.E., Wingsley, P.B., Ogg, R.J., Pui, M.H., Kun, L.E., Jenkins, J.J. 3rd, Chen, G., Ochs, J.J., Sanford, R.A., and Heideman, R.L. 1996. Clinical value of proton magnetic resonance spectroscopy for differentiating recurrent or residual brain tumor from delayed cerebral necrosis. Int. J. Radiat. Oncol. Biol. Phys. 36:1251-1261.