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Clinical Applications of fMRI

Keith R. Thulborn¹, Denise Davis¹

¹University of Illinois at Chicago, Chicago, Illinois

Publication Name:

Current Protocols in Magnetic Resonance Imaging

Unit Number:

Unit A6.1

DOI:

10.1002/0471142719.mia0601s00

Online Posting Date:

May, 2001

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Abstract

The clinical scenario in which fMRI is requested by a referring physician is usually after detection of a lesion in the brain of a patient for whom surgical intervention is being contemplated. This unit discusses the suitable parameters of a functional MRI system and also presents the Basic Protocol for imaging language function.

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Unit Introduction
Basic Protocol: Imaging Language Function
Commentary
Bibliography
Figures
Tables

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Figures

Figure A6.1.1

Representative activation map at 3.0 T for language paradigm, showing extensive network activation with areas of fronta eye fields (FEF, precentral sulcus), supplementary eye fields (SEF, medial frontal cortex), prefrontal cortex (PFC), intraparietal sulcus (IPS), Broca's area (BA, left inferior frontal cortex), Wernicke's area (WA, left superior temporal gyrus), and visual cortex (calcarine sulcus). This pattern is observed in adults irrespective of gender or handedness. The right inferior frontal cortex also shows activation in the contralateral location to Broca's area as can sometimes be observed with Wernicke's area. The color scale indicates the t-test statistic for activation. The higher t-statistic (yellow) has greater statistical significance. See color plate.

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Literature Cited

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Key Reference
	Moonen, C. and Bandettini, P. (eds.) 1999. Medical Radiology: Diagnostic Imaging and Radiation Oncology, Functional MRI. Springer-Verlag, Berlin.
Comprehensive book on all issues related to fMRI