Quality Assurance for Clinical fMRI
1University of Illinois at Chicago, Chicago, Illinois
Abstract
The functional MRI (fMRI) procedure has several sources of variance that determine the success of the examination. These include the scanner, patient, and paradigm. As blood oxygenation level dependent (BOLD) contrast is a small effect, high signal-to-noise performance is mandatory. Because the preparation of a functional activation map requires averaging multiple images over time, the scanner must produce high temporal stability of the signal intensity. This unit presents the
Materials
Basic Protocol: Scanner Stability
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Spherical phantom in loader with doped water, 16-cm diameter
Figures
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Figure A6.2.1Representative results of the quality assurance protocol for one day from a 1.5 T scanner. (A) Normalized signal intensity over 512 images showing a peak-to-peak variation of less than 1%. (B) Signal-to-noise ratio over 512 images showing a mean value above 300. (C) Percentage ghosting over 512 images showing a mean value of less than 2%.
Literature Cited
| Literature Cited | |
| Thulborn, K.R. 1999. Quality assurance in clinical and research echo-planar functional MRI. In Medical Radiology: Diagnostic Imaging and Radiation Oncology. Functional MRI (C. Moonen and P. Bandettini, eds.) pp. 337-345. Springer-Verlag, Berlin. | |
| Thulborn, K.R. and Gisbert, A. 2000. Clinical Applications of Mapping Neurocognitive Processes in the Human Brain with Functional MRI. (P. Matthews and P. Jezzard, eds.) Oxford University Press, Oxford. In press. | |
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