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Quality Assurance for Clinical fMRI

Keith R. Thulborn1,  Denise Davis1

1University of Illinois at Chicago, Chicago, Illinois

Unit Number: 
Unit A6.2
DOI: 
10.1002/0471142719.mia0602s00
Online Posting Date: 
May, 2001
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Abstract

The functional MRI (fMRI) procedure has several sources of variance that determine the success of the examination. These include the scanner, patient, and paradigm. As blood oxygenation level dependent (BOLD) contrast is a small effect, high signal-to-noise performance is mandatory. Because the preparation of a functional activation map requires averaging multiple images over time, the scanner must produce high temporal stability of the signal intensity. This unit presents the Basic Protocol for achieving scanner stability. There are many determinants of such performance but not all possibilities need to be checked separately. An adequate approach has been to verify total system performance under the conditions of a functional MRI study on a phantom. This testing is done daily prior to patient studies.

     
 
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Table of Contents

  • Unit Introduction
  • Basic Protocol: Scanner Stability
  • Commentary
  • Literature Cited
  • Figures
  • Tables
     
 
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Materials

Basic Protocol: Scanner Stability

 Materials
  • Spherical phantom in loader with doped water, 16-cm diameter
     
 
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Figures

  • Figure A6.2.1
    Representative results of the quality assurance protocol for one day from a 1.5 T scanner. (A) Normalized signal intensity over 512 images showing a peak-to-peak variation of less than 1%. (B) Signal-to-noise ratio over 512 images showing a mean value above 300. (C) Percentage ghosting over 512 images showing a mean value of less than 2%.

Literature Cited

Literature Cited
    Thulborn, K.R. 1999. Quality assurance in clinical and research echo-planar functional MRI. In Medical Radiology: Diagnostic Imaging and Radiation Oncology. Functional MRI (C. Moonen and P. Bandettini, eds.) pp. 337-345. Springer-Verlag, Berlin.
    Thulborn, K.R. and Gisbert, A. 2000. Clinical Applications of Mapping Neurocognitive Processes in the Human Brain with Functional MRI. (P. Matthews and P. Jezzard, eds.) Oxford University Press, Oxford. In press.
     
 
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